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81377  München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Professor. Haass started to work on Alzheimer's disease (AD) rein 1990 at a time, when very little welches known about the cellular mechanisms involved.  Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß.  Christian Haass hypothesized against the widely accepted general opinion in this field that Aß may be produced from its precursor rein a physiologically gewöhnlich pathway and not necessarily rein a pathological process.  Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions.  This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved in generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production rein patients.

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Hinein addition, you can use our „Learning to drive“ app to extend your knowledge – wherever and whenever you wish. With this Potpourri of classroom study and app Weiterbildung you will be fully prepared for the theoretical test.

Yes, you can, but the Schulung contract only becomes valid when it is signed by your father or mother.

Is it possible for a good driving student to register for the test after having lessons only hinein special driving situations? No, that is not possible because of the legal regulations.

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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects.  Christian Haass welches the first to demonstrate a physiological function for beta-secretase.  He showed that this protease is critically required for the regulation of myelination.  Furthermore, he identified a novel APP processing pathway, which was overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors.  He welches also the first to identify the highly complicated subunit composition of gamma-secretase.  All these findings not only helped to understand several signaling pathways critically involved hinein brain development (such as myelination and cell differentiation) but also provided the Lager for several current therapeutic approaches.

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Momo’s Driving School rein Munich also offers refresher courses for licence-holders World health organization want to optimise their driving skills or World health organization have not driven for a long time and want to gather practical driving experience accompanied by a driving instructor.

einer elektrischen Antriebsmaschine oder einem Verbrennungsmotor mit einem Hubraum von nicht eine größere anzahl wie 50 cm³ oder

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